Dose-Dependent Effects of Snakehead Fish (Channa Striata) Oil Extract on Lipid Profile and Inflammatory Markers in Diet-Induced Dyslipidemic Rats

Gratify Ayu Dwi Anjani; Titiek Sumarawati; Chodijah Chodijah

doi:10.70716/mohr.v4i2.471

Authors

Gratify Ayu Dwi Anjani Sultan Agung Islamic University of Semarang, Semarang, Indonesia
Titiek Sumarawati Sultan Agung Islamic University of Semarang, Semarang, Indonesia
Chodijah Chodijah Sultan Agung Islamic University of Semarang, Semarang, Indonesia

DOI:

https://doi.org/10.70716/mohr.v4i2.471

Keywords:

Channa striata, dyslipidemia, omega-3 fatty acids, inflammation, HDL

Abstract

Dyslipidemia is a major cardiovascular risk factor closely associated with chronic inflammation. Snakehead fish (Channa striata) contains omega-3 fatty acids and bioactive peptides with lipid-modulating and anti-inflammatory potential. However, its dose-dependent effects on lipid and inflammatory parameters remain unclear. This study investigated the dose-dependent effects of C. striata oil extract on lipid profile and inflammatory markers in diet-induced dyslipidemic rats. Twenty-four male Wistar rats were randomized into four groups (n=6): normal control, dyslipidemia model, low-dose extract (150 mg/kgBW), and high-dose extract (250 mg/kgBW). Dyslipidemia was induced using quail egg yolk (4 mL/kgBW/day) for 14 days, while treatments were administered orally. Serum LDL, HDL, TNF-α, and IL-10 levels were analyzed using spectrophotometry and ELISA. Dyslipidemia induction significantly increased LDL and TNF-α and reduced HDL and IL-10 (p<0.001). Both extract doses improved all parameters, with the 250 mg/kgBW dose producing the strongest effects: LDL reduction of 55%, HDL restoration to 76% of control, TNF-α reduction of 64%, and IL-10 elevation to 74% of control. These findings demonstrate clear dose-response effects. C. striata oil extract exhibits significant anti-dyslipidemic and anti-inflammatory properties, supporting its potential as a natural adjunct therapy for dyslipidemia management.

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