Micronutrient Intake and Preeclampsia: The Protective Role of Vitamins C and D

Authors

  • Siska Indrayani Program Studi S1-Kebidanan, FMIPAKES, Universitas Muhammadiyah Riau, Pekanbaru, Indonesia.
  • Rina Oktaviana Program Studi Pendidikan Profesi Bidan, FMIPAKES, Universitas Muhammadiyah Riau, Pekanbaru, Indonesia.

DOI:

https://doi.org/10.70716/mohr.v4i2.428

Keywords:

Preeclampsia, vitamin c, vitamin D, micronutrient intake, pregnancy nutrition

Abstract

Preeclampsia is a major hypertensive disorder of pregnancy that contributes significantly to maternal and perinatal morbidity. This study aimed to examine the association between maternal micronutrient intake, particularly vitamin C and vitamin D, and the occurrence of preeclampsia among pregnant women. A case–control study was conducted in Padang, West Sumatra, involving 66 pregnant women in the third trimester: 33 with preeclampsia and 33 without. Micronutrient intake was assessed using a Semi-Quantitative Food Frequency Questionnaire. Data were analyzed using the Mann–Whitney test and logistic regression analysis. The results showed significant differences in vitamin C and vitamin D intake between the two groups. Multivariate analysis indicated that vitamin D intake and maternal education level were significantly associated with preeclampsia, whereas vitamin C intake was not significantly associated after adjustment for confounding variables. These findings suggest that adequate vitamin D intake during pregnancy may help reduce the risk of preeclampsia. Nutritional interventions during antenatal care may help improve maternal health outcomes.

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References

Aldi, Y., Afriwardi, Badriyya, E., Azukhruf, W. S., & Alianta, A. A. (2023). Effects of Pegagan Embun (Hydrocotyle sibthorpioides Lam) Extract on Renal Function in Male Wistar Rats as Assessed by Creatinine Clearance. Tropical Journal of Natural Product Research, 7(3), 2547–2550. https://doi.org/10.26538/tjnpr/v7i3.13

AlSubai, A., Baqai, M. H., Agha, H., Shankarlal, N., Javaid, S. S., Jesrani, E. K., Golani, S., Akram, A., Qureshi, F., Ahmed, S., & Saran, S. (2023). Vitamin D and preeclampsia: A systematic review and meta-analysis. Sage Open Medicine, 11. https://doi.org/10.1177/20503121231212093

Chalas, E. (2020). The American College of Obstetricians and Gynecologists in 2020: A Clear Vision for the Future. Obstetrics and Gynecology, 135(6), 1251–1254. https://doi.org/10.1097/AOG.0000000000003899

Chen, S., Huang, D., & Cheng, W. (2025). Analysis of serological risk factors for preeclampsia and the predictive role of high homocysteine levels. American Journal of Translational Research, 17(5), 3465–3475. https://doi.org/10.62347/IKIP3300

Cristófalo, M. M., de Almeida Garcia, J. O., Aldrighi, J. F. S., Cristófalo, R. M., França, M. L. M., Luzia, L. A., Vasconcelos, S. P., & Aldrighi, J. M. (2026). Prevalence of Vitamin D Deficiency in Pregnant Women: Systematic Review and Meta-analysis. Nutrition Reviews, 84(3), 600–614. https://doi.org/10.1093/nutrit/nuaf168

Gernand, A. D., Schulze, K. J., Stewart, C. P., West, K. P. J., & Christian, P. (2016). Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nature Reviews. Endocrinology, 12(5), 274–289. https://doi.org/10.1038/nrendo.2016.37

Gerovasili, E., Sarantaki, A., Bothou, A., Deltsidou, A., Dimitrakopoulou, A., & Diamanti, A. (2025). The role of vitamin D deficiency in placental dysfunction: A systematic review. Metabolism Open, 25, 100350.

Giourga, C., Papadopoulou, S. K., Voulgaridou, G., Karastogiannidou, C., Giaginis, C., & Pritsa, A. (2023). Vitamin D Deficiency as a Risk Factor of Preeclampsia during Pregnancy. Diseases (Basel, Switzerland), 11(4). https://doi.org/10.3390/diseases11040158

Hu, K., Zhang, C., & Chen, P. (2022). Vitamin D Levels in Early and Middle Pregnancy and Preeclampsia: A Systematic Review and Meta-Analysis. Frontiers In Nutrition, 9, 863428. https://doi.org/10.3389/fnut.2022.863428

Ibrahim, Y., Mohd Jamil, A. A., Nordin, N., Loh, S. P., & Basri, N. I. (2026). Maternal Vitamin D Deficiency and Its Effects on Pregnancy Outcomes. Food Science & Nutrition, 14(1). https://doi.org/10.1002/fsn3.71377

Keats, E. C., Haider, B. A., Tam, E., & Bhutta, Z. A. (2021). Multiple-Micronutrient Supplementation for Women During Pregnancy. Cochrane Database Of Systematic Reviews, 11. https://doi.org/10.1002/14651858.CD004905.pub6

Kokkinari, A., Gourounti, K., Dagla, M., Tsinisizeli, N., & Iatrakis, G. (2025). Maternal Vitamin D Status, Gestational Hypertension, and Preeclampsia: A Cross-Sectional Study in Urban Greece. Biomedicines, 13(11). https://doi.org/10.3390/biomedicines13112624

Malm, G., Lindh, C., & Hansson, S. (2023). Maternal Serum Vitamin D Level in Early Pregnancy and Risk for Preeclampsia: A Case-Control Study in Southern Sweden. PLOS ONE, 18(2), e0281234.

Mészáros, B., Veres, D. S., Nagyistók, L., Kovács, B. G., Kukor, Z., & Valent, S. (2024). A meta-analysis on first-trimester blood count parameters: Is the neutrophil-to-lymphocyte ratio a potentially novel method for first-trimester preeclampsia screening? Frontiers in Medicine, 11, 1336764. https://doi.org/10.3389/fmed.2024.1336764

Ministry of Health, Republic of Indonesia. (2023). Indonesia Health Profile 2022. Ministry of Health, Republic of Indonesia. https://www.kemkes.go.id

Moghib, K., Ghanm, T. I., Abunamoos, A., Rajabi, M., Moawad, S. M., Mohsen, A., Kasem, S., Elsayed, K., Sayed, M., Dawoud, A. I., Salomon, I., Elmaghreby, A., Ismail, M., & Amer, A. (2024). Efficacy of vitamin D supplementation on the incidence of preeclampsia: a systematic review and meta-analysis. BMC Pregnancy and Childbirth, 24(1), 852. https://doi.org/10.1186/s12884-024-07081-y

Purswani, J., Gala, P., Dwarkanath, P., Larkin, H. M., Kurpad, A., & Mehta, S. (2017). The Role of Vitamin D in Preeclampsia: A Systematic Review. BMC Pregnancy And Childbirth, 17, 231. https://doi.org/10.1186/s12884-017-1408-3

Serrano-Díaz, N. C., Gamboa-Delgado, E. M., Domínguez-Urrego, C. L., Vesga-Varela, A. L., Serrano-Gómez, S. E., & Quintero-Lesmes, D. C. (2018). Vitamin D and risk of preeclampsia: A systematic review and meta-analysis. Biomedica, 38(1), 43–53. https://doi.org/10.7705/biomedica.v38i0.3683

Stevens, G. A., Beal, T., Mbuya, M. N. N., Luo, H., Neufeld, L. M., & Group, G. M. D. R. (2022). Micronutrient Deficiencies Among Preschool-Aged Children and Women of Reproductive Age Worldwide: A Pooled Analysis of Individual-Level Data from Population-Representative Surveys. The Lancet Global Health, 10(11), e1590–e1599. https://doi.org/10.1016/S2214-109X(22)00367-9

Ushida, T., Tano, S., Matsuo, S., Fuma, K., Imai, K., Kajiyama, H., & Kotani, T. (2025). Dietary supplements and prevention of preeclampsia. Hypertension Research, 48(4), 1444–1457. https://doi.org/10.1038/s41440-025-02144-9

Wei, S. Q., Audibert, F., & Hidiroglou, N. (2012). Longitudinal Vitamin D Status in Pregnancy and the Risk of Preeclampsia. BJOG: An International Journal Of Obstetrics & Gynaecology, 119(7), 832–839. https://doi.org/10.1111/j.1471-0528.2012.03307.x

World Health Organization. (2021). WHO recommendations on antenatal care for a positive pregnancy experience. https://www.who.int/publications/i/item/9789241549912

World Health Organization. (2023). Trends in maternal mortality 2000 to 2020: Estimates by WHO, UNICEF, UNFPA, World Bank Group and UNDESA/Population Division. https://www.who.int/publications/i/item/9789240068759

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Published

2026-05-23

How to Cite

Indrayani, S., & Oktaviana, R. (2026). Micronutrient Intake and Preeclampsia: The Protective Role of Vitamins C and D. Media of Health Research, 4(2), 148–158. https://doi.org/10.70716/mohr.v4i2.428