Effectiveness of Mobile Health Applications in Improving Medication Adherence among Hypertension Patients
DOI:
https://doi.org/10.70716/mohr.v3i3.312Keywords:
mobile health, medication adherence, hypertension, digital health, self-managementAbstract
Hypertension remains a major global health concern due to its high prevalence and association with cardiovascular complications. Poor medication adherence is one of the leading factors contributing to uncontrolled blood pressure, resulting in adverse health outcomes. Recent advances in digital health, particularly mobile health (mHealth) applications, have been widely used to support self-management of chronic diseases. This study aimed to evaluate the effectiveness of mHealth applications in improving medication adherence among hypertensive patients. A quasi-experimental study was conducted with 120 participants randomly assigned into intervention and control groups. The intervention group used an mHealth application designed to provide medication reminders, educational content, and self-monitoring tools for 12 weeks, while the control group received standard care. Adherence levels were measured using the Morisky Medication Adherence Scale (MMAS-8), and blood pressure control was also assessed. Results indicated a significant improvement in adherence scores in the intervention group compared to the control group (p < 0.01). Additionally, systolic and diastolic blood pressure levels were better controlled among patients using the application. These findings suggest that mHealth applications can effectively enhance medication-taking behavior and contribute to better hypertension management. Further studies with larger samples and longer follow-up are recommended to confirm long-term sustainability and cost-effectiveness.
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Al-Arkee, S., Mason, J., Lane, D. A., Fabritz, L., Chua, W., Haque, M. S., & Tayebjee, M. H. (2021). Mobile apps to improve medication adherence in cardiovascular disease: Systematic review and meta-analysis. Journal of Medical Internet Research, 23(5), e24190. https://doi.org/10.2196/24190
Armitage, L. C., Kassavou, A., & Sutton, S. (2020). Do mobile device apps designed to support medication adherence demonstrate efficacy? A systematic review of randomized controlled trials, with meta-analysis. BMJ Open, 10(1), e032045. https://doi.org/10.1136/bmjopen-2019-032045
Brown, M. T., & Bussell, J. K. (2011). Medication adherence: WHO cares? Mayo Clinic Proceedings, 86(4), 304–314. https://doi.org/10.4065/mcp.2010.0575
Dong, J., Reeves, L., Ali, A., & Li, L. (2018). A systematic review of the effectiveness of text message reminders on asthma medication adherence. Innovations in Pharmacy, 9(3), 1–7. https://doi.org/10.24926/iip.v9i3.1370
Duan, Y., Shang, B., Liang, W., Du, G., Yang, M., & Rhodes, R. E. (2021). Effects of eHealth-based multiple health behavior change interventions on physical activity, healthy diet, and weight in people with noncommunicable diseases: Systematic review and meta-analysis. Journal of Medical Internet Research, 23(2), e23786. https://doi.org/10.2196/23786
Gong, K., Yan, Y. L., Li, Y., Du, J., Wang, J., Han, Y., ... & She, Q. (2020). Mobile health applications for the management of primary hypertension: A multicenter, randomized, controlled trial. Medicine, 99(16), e19715. https://doi.org/10.1097/MD.0000000000019715
Lanke, V., Trimm, K., Habib, B., & Tamblyn, R. (2025). Evaluating the effectiveness of mobile apps on medication adherence for chronic conditions: Systematic review and meta-analysis. Journal of Medical Internet Research, 27, e60822. https://doi.org/10.2196/60822
Marcolino, M. S., Oliveira, J. A. Q., D’Agostino, M., Ribeiro, A. L., Alkmim, M. B. M., & Novillo-Ortiz, D. (2018). The impact of mHealth interventions: Systematic review of systematic reviews. JMIR mHealth and uHealth, 6(1), e23. https://doi.org/10.2196/mhealth.8873
Mikulski, B. S., Bellei, E. A., Biduski, D., & De Marchi, A. C. B. (2022). Mobile health applications and medication adherence of patients with hypertension: A systematic review and meta-analysis. American Journal of Preventive Medicine, 62(4), 626–634. https://doi.org/10.1016/j.amepre.2021.11.003
Mills, K. T., Stefanescu, A., & He, J. (2020). The global epidemiology of hypertension. Nature Reviews Nephrology, 16(4), 223–237. https://doi.org/10.1038/s41581-019-0244-2
Morawski, K., Ghazinouri, R., Krumme, A., McDonough, J., Durfee, E., Oley, L., ... & Choudhry, N. K. (2018). Association of a smartphone application with medication adherence and blood pressure control: The MedISAFE-BP randomized clinical trial. JAMA Internal Medicine, 178(6), 802–809. https://doi.org/10.1001/jamainternmed.2018.0447
Morisky, D. E., Ang, A., Krousel-Wood, M., & Ward, H. J. (2008). Predictive validity of a medication adherence measure in an outpatient setting. The Journal of Clinical Hypertension, 10(5), 348–354. https://doi.org/10.1111/j.1751-7176.2008.07572.x
Morrison, D., Wyke, S., Agur, K., Cameron, E. J., Docking, R. I., Mackenzie, A. M., ... & Mair, F. S. (2014). Digital asthma self-management interventions: A systematic review. Journal of Medical Internet Research, 16(2), e51. https://doi.org/10.2196/jmir.2814
Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., ... & Haynes, R. B. (2014). Interventions for enhancing medication adherence. Cochrane Database of Systematic Reviews, 2014(11), CD000011. https://doi.org/10.1002/14651858.CD000011.pub4
Peng, Y., Wang, H., Fang, Q., Chen, Y., Ma, X., & Yang, J. (2020). Effectiveness of mobile applications on medication adherence in adults with chronic diseases: A systematic review and meta-analysis. Journal of Managed Care & Specialty Pharmacy, 26(4), 550–561. https://doi.org/10.18553/jmcp.2020.26.4.550
Pérez-Jover, V., Sala-González, M., Guilabert, M., & Mira, J. J. (2019). Mobile apps for increasing treatment adherence: Systematic review. Journal of Medical Internet Research, 21(6), e12505. https://doi.org/10.2196/12505
Persell, S. D., Peprah, Y. A., Lipiszko, D., Lee, J. Y., Li, J. J., Ciolino, J. D., ... & Sato, H. (2020). Effect of home blood pressure monitoring via a smartphone hypertension coaching application or tracking application on adults with uncontrolled hypertension: A randomized clinical trial. JAMA Network Open, 3(3), e200255. https://doi.org/10.1001/jamanetworkopen.2020.0255
Santo, K., Richtering, S. S., Chalmers, J., Thiagalingam, A., Chow, C. K., & Redfern, J. (2018). Mobile phone apps to improve medication adherence: A systematic stepwise process to identify high-quality apps. JMIR mHealth and uHealth, 6(9), e132. https://doi.org/10.2196/mhealth.6742
Schoenthaler, A., Lancaster, K. J., Chaplin, W., Butler, M., Forsyth, J., Ogedegbe, G., & Allegrante, J. P. (2020). Development and evaluation of a tailored mHealth intervention to improve medication adherence in Blacks with uncontrolled hypertension and type 2 diabetes: Pilot randomized feasibility trial. JMIR mHealth and uHealth, 8(9), e17135. https://doi.org/10.2196/17135
Shi, C. (2013). Mobile phone messaging for facilitating self-management of long-term illnesses: Summaries of Nursing Care-Related Systematic Reviews from the Cochrane Library. JBI Evidence Implementation, 11(4), 344–345. https://doi.org/10.1111/1744-1609.12041
Vrijens, B., Antoniou, S., Burnier, M., de la Sierra, A., & Volpe, M. (2017). Current situation of medication adherence in hypertension. Frontiers in Pharmacology, 8, 100. https://doi.org/10.3389/fphar.2017.00100
WHO. (2021). Hypertension. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/hypertension
Xiong, S., Berkhouse, H., Schooler, M., Pu, W., Sun, A., Gong, E., & Yan, L. L. (2018). Effectiveness of mHealth interventions in improving medication adherence among people with hypertension: A systematic review. Current Hypertension Reports, 20(10), 86. https://doi.org/10.1007/s11906-018-0886-7
Yuting, Z., Xiaodong, T., & Qun, W. (2023). Effectiveness of a mHealth intervention on hypertension control in a low-resource rural setting: A randomized clinical trial. Frontiers in Public Health, 11, 1049396. https://doi.org/10.3389/fpubh.2023.1049396
Zullig, L. L., & Bosworth, H. B. (2017). Engaging patients to optimize medication adherence. BMJ, 356, j153. https://doi.org/10.1136/bmj.j153
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