Profil Paramater Inflamasi Albumin Dan Prokalsitonin Pada Kasus Pasien Covid-19

Authors

  • Amellya Octifani Universitas Anwar Medika Sidoarjo

DOI:

https://doi.org/10.70716/mohr.v1i3.24

Keywords:

Albumin, Covid-19, Inflamasi, Prokalsitonin

Abstract

Patients with COVID-19 have increased serum levels of Procalcitonin and decreased albumin, a key inflammatory marker associated with a high risk of organ injury and death. This study aims to determine the profile of inflammatory parameters albumin and procalcitonin in covid-19 patient cases. The type of research used is retrospective with a cross sectional approach. The research data were taken using a simple random sampling technique. Analysis for albumin with severity in COVID-19 positive patients in this study used an optimal limit or cut-off value of 3.5 g/dL. The optimal limit or cut off value for Procalcitonin in this study was 0.05 µg/L. The results of research from 30 patient data showed that there was a decrease in albumin levels in moderate and severe patients by 60% and an increase in procalcitonin levels > 0.05 µg/L by 96%. The conclusion of this study is that there was a decrease in albumin levels and an increase in procalcitonin levels in COVID-19 case patients, which indicates inflammation due to SARS-COV2 virus infection.

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References

Bao, J., Li, C., Zhang, K., Kang, H., Chen, W., & Gu, B. (2020). Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19. Clinica Chimica Acta, 509(January), 180–194. https://doi.org/10.1016/j.cca.2020.06.009

Bernardi, M., Angeli, P., Claria, J., Moreau, R., Gines, P., Jalan, R., Caraceni, P., Fernandez, J., Gerbes, A. L., O’Brien, A. J., Trebicka, J., Thevenot, T., & Arroyo, V. (2020). Albumin in decompensated cirrhosis: New concepts and perspectives. Gut, 69(6), 1127–1138. https://doi.org/10.1136/gutjnl-2019-318843

Catanzaro, M., Fagiani, F., Racchi, M., Corsini, E., Govoni, S., & Lanni, C. (2020). Immune response in COVID-19: Addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2. Signal Transduction and Targeted Therapy, 5(1). https://doi.org/10.1038/s41392-020-0191-1

Dharma, B. D. A., Mulyantari, N. K., & Prabawa, I. P. Y. (2020). Analisis korelasi kadar serum prokalsitonin dengan jumlah leukosit pada penderita dengan kecurigaan sepsis di RSUP Sanglah, Bali, Indonesia. Intisari Sains Medis, 11(1), 179–182. https://doi.org/10.15562/ism.v11i1.525

Di Gennaro, F., Pizzol, D., Marotta, C., Antunes, M., Racalbuto, V., Veronese, N., & Smith, L. (2020). Coronavirus diseases (COVID-19) current status and future perspectives: A narrative review. International Journal of Environmental Research and Public Health, 17(8), 2690. https://doi.org/10.3390/ijerph17082690

Gargouri, M., Alzwi, A., & Abobaker, A. (2020). Cyclin dependent kinase inhibitors as a new potential therapeutic option in management of COVID-19. Medical Hypotheses, 146, 110380. https://doi.org/10.1016/j.mehy.2020.110380

Handayani, N., Lardo, S., & Nugrohowati, N. (2021). Difference of procalcitonin levels in Gram-positive and Gram-negative bacterial sepsis patients of Indonesia Army Central Hospital Gatot Soebroto in 2016. JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, 13(1), 38–41. https://doi.org/10.20473/juxta.v13i1.2022.38-41

Han, H., Yang, L., Liu, R., Liu, F., Wu, K. L., Li, J., Liu, X. H., & Zhu, C. L. (2020). Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clinical Chemistry and Laboratory Medicine, 58(7), 1116–1120. https://doi.org/10.1515/cclm-2020-0188

Harapan, H., Itoh, N., Yufika, A., Winardi, W., Keam, S., Te, H., & Mudatsir, M. (2020). Coronavirus disease 2019 (COVID-19): A literature review. Journal of Infection and Public Health, 13(5), 667–673. https://doi.org/10.1016/j.jiph.2020.03.019

Heininger, U. (2020). Severe acute respiratory syndrome coronavirus 2 vaccines: Setting expectations appropriately. Pediatric Infectious Disease Journal, 39(1), e123–e124. https://doi.org/10.1097/INF.0000000000002741

Jagdish, R. K., Maras, J. S., & Sarin, S. K. (2021). Albumin in advanced liver diseases: The good and bad of a drug! Hepatology, 74(5), 2848–2862. https://doi.org/10.1002/hep.31836

Jiang, S., Shi, Z., Shu, Y., Song, J., Gao, G. F., Tan, W., & Guo, D. (2020). A distinct name is needed for the new coronavirus. The Lancet, 395(10228), 949. https://doi.org/10.1016/S0140-6736(20)30419-0

Kao, C. M., Orenstein, W. A., & Anderson, E. J. (2021). The importance of advancing severe acute respiratory syndrome coronavirus 2 vaccines in children. Clinical Infectious Diseases, 72(3), 515–518. https://doi.org/10.1093/cid/ciaa712

Lasne, D., Jude, B., & Susen, S. (2006). From normal to pathological hemostasis. Canadian Journal of Anesthesia, 53(S2), S2–S11. https://doi.org/10.1007/BF03022254

Manssor, B., Patel, J., & Parekh, D. (2020). Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The Lancet Gastroenterology & Hepatology, 5(5), 428–430. https://doi.org/10.1016/S2468-1253(20)30057-1

Naqvi, A. A. T., Fatima, K., Mohammad, T., Fatima, U., Singh, I. K., Singh, A., Atif, S. M., Hariprasad, G., Hasan, G. M., & Hassan, M. I. (2020). Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1866(10), 165878. https://doi.org/10.1016/j.bbadis.2020.165878

Palta, S., Saroa, R., & Palta, A. (2014). Overview of the coagulation system. Indian Journal of Anaesthesia, 58(5), 515–523. https://doi.org/10.4103/0019-5049.144643

Pourbagheri-Sigaroodi, A., Bashash, D., Fateh, F., & Abolghasemi, H. (2020). Laboratory findings in COVID-19 diagnosis and prognosis. Clinica Chimica Acta, 510, 475–482. https://doi.org/10.1016/j.cca.2020.08.019

Talera, S., Singhal, S., Wadhera, N., Arora, M., & Pratap, R. (2021). Serum albumin level as a prognostic marker for COVID-19 positive patients in Western Uttar Pradesh: A cross-sectional study. Journal of Evidence Based Medicine and Healthcare, 8(4), 204–207. https://doi.org/10.18410/jebmh/2021/39

Tufan, A., Avanoğlu Güler, A., & Matucci-Cerinic, M. (2020). COVID-19, immune system response, hyperinflammation, and repurposing antirheumatic drugs. Turkish Journal of Medical Sciences, 50(SI-1), 620–632. https://doi.org/10.3906/sag-2004-168

Umar, I., & Sujud, R. W. (2020). Hemostasis dan disseminated intravascular coagulation (DIC). Journal of Anaesthesia and Pain, 1(2), 19–32.

Violi, F., Cangemi, R., Romiti, G. F., Ceccarelli, G., Oliva, A., Alessandri, F., Pirro, M., Pignatelli, P., Lichtner, M., Carraro, A., Cipollone, F., D’Ardes, D., Pugliese, F., & Mastroianni, C. M. (2021). Is albumin predictor of mortality in COVID-19? Antioxidants and Redox Signaling, 35(2), 139–142. https://doi.org/10.1089/ars.2020.8142

Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., Tai, Y., Bai, C., Gao, T., Song, J., Xia, P., Dong, J., Zhao, J., & Wang, F. S. (2020). Pathological findings of COVID-19 associated with acute respiratory distress syndrome. The Lancet Respiratory Medicine, 8(4), 420–422. https://doi.org/10.1016/S2213-2600(20)30076-X

Yang, L., Liu, S., Liu, J., Zhang, Z., Wan, X., Huang, B., & Zhang, Y. (2020). COVID-19: Immunopathogenesis and immunotherapeutics. Signal Transduction and Targeted Therapy, 5(1), 128. https://doi.org/10.1038/s41392-020-00243-2

Zhang, C., Shi, L., & Wang, F. S. (2020). Liver injury in COVID-19: Management and challenges. The Lancet Gastroenterology & Hepatology, 5(5), 428–430. https://doi.org/10.1016/S2468-1253(20)30057-1

Zou, Y., Guo, H., Zhang, Y., Zhang, Z., Liu, Y., Wang, J., & Qian, Z. (2020). Analysis of coagulation parameters in patients with COVID-19 in Shanghai, China. Bioscience Trends, 14(4), 285–289. https://doi.org/10.5582/bst.2020.03086

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Published

2023-12-21

How to Cite

Octifani, A. (2023). Profil Paramater Inflamasi Albumin Dan Prokalsitonin Pada Kasus Pasien Covid-19. Media of Health Research, 1(3), 85–90. https://doi.org/10.70716/mohr.v1i3.24